HLH researchers explore new drugs, gene therapy

Calming a Storm in the Immune System

HLH researchers explore new drugs, gene therapy

Although science has come a long way in understanding HLH, its treatment presents significant challenges. Each step in treatment – getting the raging immune response under control, then replacing the immune system with bone marrow transplantation – wages its own set of assaults on young bodies. Cincinnati Children’s physician-researchers are working to find more effective, less toxic alternatives.

Combination Therapy

One approach is a multicenter clinical trial led by Michael Jordan, MD, of theDivision of Bone Marrow Transplantation and Immune Deficiency. The trial combines two currently used approaches into a unique treatment, “hybrid immunotherapy.” It is designed to improve the first step of treating HLH – quieting the inflammatory response. The Hybrid Immunotherapy for HLH (HIT-HLH) trial is the first-ever U.S.-based trial for the condition and the only one funded by the NIH. It involves 10 centers throughout the U.S. and Canada.

To read the full story click on the link: http://www.cincinnatichildrens.org/professional/resources/research-horizons/archives/2013/winter/calming-storm/

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