BMT #2 – Liam will receive the same conditioning that he received for his 1st transplant, plus they will be adding Anti-thymocyte globulin (ATG) for 3 days. They said this has been added to help increase his engraftment. His 2nd Bone Marrrow Transplant is scheduled for March 6, 2013.
BMT #1 – Liam received reduced intensity conditioning with Treosulfan and Fludarabine (research Protocol 2256) regimen A.
The standard protocol for reduced intensity conditioning is Fludarabine, Campath & Melphalan.
Protocol 2256 – Treosulfan and Fludarabine Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders
Source: http://clinicaltrials.gov/show/NCT00919503
The purpose of this phase II clinical trial is to see if the combination of two chemotherapy drugs, treosulfan and fludarabine with or without low dose radiation, just prior to stem cell transplantation is safe and effective in patients with nonmalignant (noncancerous) diseases. Hematopoietic cell transplantation has been shown to be curative for many patients with nonmalignant (noncancerous) diseases such as primary immunodeficiency disorders, bone marrow failure syndromes, hemoglobinopathies, and inborn errors of metabolism (metabolic disorders). Powerful chemotherapy drugs and/or radiation are often used to condition the patient before infusion of the new healthy donor cells. The purpose of the conditioning therapy is to destroy the patient’s abnormal bone marrow which doesn’t work properly in order to make way for the new healthy donor cells which functions normally. Although effective in curing the patient’s disease, many hematopoietic cell transplantation regimens use intensive chemotherapy and/or radiation which can be quite toxic, have significant side effects, and can potentially be life-threatening. Investigators at the Fred Hutchinson Cancer Research Center in collaboration with Oregon Health & Sciences University and Medical College of Wisconsin are investigating whether a new conditioning regimen that uses less intensive drugs (treosulfan and fludarabine) with or without low dose radiation results in engraftment of the new donor cells without increased toxicities in patients with nonmalignant (noncancerous) diseases
Bone Marrow Transplant
RATIONALE: Giving low doses of chemotherapy and total-body irradiation before a donor stem cell transplant helps stop the growth of abnormal cells. It may also stop the patient’s immune system from rejecting the donor’s stem cells. The donated stem cells may replace the patient’s immune cells and help destroy any remaining abnormal cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body’s normal cells. Giving tacrolimus, methotrexate, cyclosporine, and mycophenolate mofetil before and after transplant may stop this from happening.
PURPOSE: This phase II trial is studying how well giving treosulfan together with fludarabine phosphate followed by donor stem cell transplant works in treating patients with noncancerous inherited disorders.
http://www.fhcrc.org/en/treatment/clinical-trials/detail.2330.html
Complete title: Pentostatin and Donor Lymphocyte Infusion for Low Donor T-Cell Chimerism After Hematopoietic Cell Transplantation Using Nonmyeloablative Conditioning – A Multicenter Trial
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Clinical Trial Detail
www.fhcrc.org/en/treatment/clinical-trials/detail.2330.htmlComplete title: Pentostatin and Donor Lymphocyte Infusionfor Low Donor T-Cell Chimerism After Hematopoietic Cell Transplantation Using Nonmyeloablative …
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www.cancer.gov/clinicaltrials/search/view?cdrid=391025…PatientThis clinical trial studies pentostatin and donor lymphocyte infusion in preventing graft rejection in patients who have undergone donor stem cell transplant.
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www.druglib.com/druginfo/nipent/Dec 9, 2011 – Pentostatin and Lymphocyte Infusion in Preventing Graft Rejection in Patients Who Have UndergoneDonor Stem Cell Transplant [Recruiting] …
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